Biometra TAdvanced

Biometra TAdvancedБольше картинок

Features

Biometra TAdvanced – the high-performance thermal cycler for DNA amplification by PCR

  • Twelve different sample blocks: including a 96-well silver block as high-end variant
  • Powerful control electronics: Now even an aluminum block reaches superior heating and cooling rates as usually only achieved in instruments with silver block
  • Fastest Ramping, Highest Accuracy and Intelligent Block/Well Control (RAC): high temperature uniformity and maximum reproducibility, no over- or undershooting of the programmed target temperature
  • Optional with gradient: simple optimization of new primer pairs
  • Linear Gradient Tool (LGT): specific adjustment of the gradient temperature profile
  • High Performance Smart Lid Technology (HPSL): fast heating, constant contact pressure and easy use
  • Quick Block Exchange System: easy, fast exchange of sample blocks
  • Whisper Quiet Technology: particularly quiet operation with a maximum noise level of 45 dB
  • Intuitive software: graphical programming and Easy Spreasheet Programming
  • Multi Step Programming: easy creation of PCR protocols during programming without the need to toggle between different windows
  • Advanced User Management (AUM): flexible user management with individual assignment of user rights for single users
  • User Specific Quick Start: no tedious searching of already used PCR programs due to the combination of Quick Start and Program Preview
  • Extended Self Test: automatic system diagnosis and documentation of PCR runs
  • Comfortable 7 inch color touch display
  • USB and Ethernet port
  • Protocol Wizard: Automatic creation of PCR protocols with few inputs

    Biometra
    TAdvanced - No Compromises in Technology

Product Info

The Biometra thermal cycler for highest demands

High-Speed Thermal Block

The Biometra TAdvanced Thermal Cycler is available with different block formats. The Quick Block Exchange technology allows an easy exchange of block modules in a few seconds. All blocks are made of aluminum and offer high ramp rates for fast protocol running times. Additionally, to achieve ultimate performance, a 96 well block made of silver is available. Due to its excellent heat conductivity, silver equilibrates extremely quickly, thus providing maximum speed and temperature uniformity. To protect the valuable silver blocks against corrosion, the block surfaces are gold plated. By the rubber sealing at the lid an encapsulated space is formed when the lid is closed. The closed room serves to improve the temperature uniformity of the sample block and avoids formation of condensed water at the final PCR cooling step. Furthermore all blocks are perfectly sealed to prevent condensed water from penetrating the Peltier elements underneath the sample block and other parts of the electronics. The Peltier elements are protected by the perfect sealings. This guarantees a longer intrument lifetime.

High-Performance Smart Lid
The Biometra TAdvanced heated lid has been optimized to heat twice as fast as with older models and thus helps to shorten protocol run times. Moreover the heated lid serves for two additional essential functions: It prevents the formation of condensed water at the reaction tube portion located above the block surface level and it ensures reliable contact between samples and thermal block by applying constant pressure. By the integrated clutch mechanism the pressure applied to the reaction tubes is always same regardless of the plastic ware height. The combination of the heated lid shape and the reliable contact pressure ensure an even temperature distribution between samples thus significantly improves the temperature uniformity.
With one press on the front button, the lid gently swings open and arrests in its end position. By this mechanism the lid cannot fall down and the heated lid is out of the radius of action when the user is inserting tubes or plates. Thus the risk of injury by violent pressure or the risk of burn by hot surfaces is prevented.

State of the Art Touchscreen (Display)
The Biometra TAdvanced Thermal Cycler features a 7`` state of the art color touchscreen user interface. The touchscreen is built-in at a flat angle to ensure reflection-free viewing and ergonomic programming. For programming of PCR protocols, the software incorporates Biometras proven spreadsheet philosophy and additionally a graphical programming mode. One touch leads from the spreadsheet to the alternative graphical programming mode. This makes the creation of new or editing existing of programs fast and easy.

User specific quick start function

Many other thermal cyclers offer a so called “latest program list”. In the latest program list a certain number of PCR programs is collected and offered for quick start. The list is typically ordered only by date and the user has to search for the desired program. In contrast the Biometra TAdvanced software creates a user specific list and only the latest programs started by the currently logged-in user are offered for quick start. Even a lab member does not use the instrument for a longer time the information on the latest programs started by this user will not get lost.
For maximum convenience the Biometra TAdvanced software features additionally features the program preview. Before start of a program the protocol steps are summarized in a clearly arranged table by the program preview tool. The program preview therefore provides a comprehensive overview on the protocol structure without the need to access programming screens. The program preview is also available before quick start of programs.

Linear Gradient Tool for maximum convenience
For optimizing new primer pairs in a single run the Biometra TAdvanced optionally can be equipped with gradient function. Finding the best primer annealing temperature is crucial for the specificity and efficiency of PCR reactions. Often optimization of experiments is conducted only limited leading to unspecific byproducts or reduced PCR sensitivity. By using the gradient function new primer pairs with unknown annealing temperatures can be tested quickly and optimized in very short time.
For maximum convenience the Biometra TAdvanced offers the Linear Gradient Tool. For most other instruments the temperature difference from row to row or from column to column in a gradient step varies across the sample block. The Biometra TAdvanced Linear Gradient Tool offers to program gradient steps with a defined temperature increment between the columns or rows. The Linear Gradient Tool option allows the comfortable creation of gradient steps and the best annealing temperature can be easily transformed to a non-gradient protocol.

Security for regulated enviroments
The software can manage up to 30 user accounts. By default three different user-levels are available: Administrator, user with generic rights and user with limited rights. However, in a comfortable menu the administrator can configure the settings for each user individually by activating or inactivating single rights. By the user administration tool in combination with the password protection of user accounts access to the instrument can be limited to authorized persons and unwanted modifications to the system settings and PCR protocols prevented.
With each system start the Biometra TAdvanced performs an initial self-test and additionally the software offers an extended self-test that can be initiated by the user. The results of the extended self-test becomes are summarized in a protocol and are stored by the instrument. Additionally to the self-test functions the instruments creates and stores run-logfiles for each single run. For long-term storage run-logfiles and extended self-test protocols can be exported as proprietary file format.

  • Fastest Ramping, highest Accuracy, Block/Well Control:
    Superior sample block temperature control
  • Whisper Quiet: Low noise emission of max. 45 dB
  • High Performance Smart Lid: Defined pressure control for
    highly reproducible results
  • Quick Block Exchange: Easy exchange of block modules thanks
    to optional QBE technology
  • ƒƒLinear Gradient Tool: For easy gradient programming using the
    primer annealing temperature
  • Protocol Wizard: Simple protocol creation by just a few inputs
  • Advanced User Management: Individual rights settings for each
    user

Technical Data

Instrument

Biometra TAdvanced 96

Biometra TAdvanced 96 S

Capacity

96 x tubes 0.2 ml
96 well microplates
12 x strips 8 well


96 x tubes 0.2 ml
96 well microplates

Block

Aluminum

Silver

Block coating

Special Alloy

Gold

Block Exchange

Quick-X-Change

Quick-X-Change

Block Exchange time

less than 10s

less than 10s

Max. heating rate*

6,0 °C/sec

8.0 °C/sec.

Max. cooling rate*

4,0 °C/sec

5.5 °C/sec.

Avg. Heating Rate*

5,5 °C/sec

7.0 °C/sec.

Avg. Cooling Rate*

3,5 °C/sec

4.5 °C/sec.

Max./min. Gradient span1

30 °C/0.1 °C

40 °C/0.1 °C

Temperature Uniformity

95 °C  ± 0.60 °C after 15 s

70 °C  ± 0.30 °C after 15 s

55 °C  ± 0.20 °C after 15 s

95 °C  ± 0.50 °C after 15 s

70 °C  ± 0.25 °C after 15 s

55 °C  ± 0.15 °C after 15 s

Gradient Temperature Range1

20 °C to 99 °C

4 °C to 99 °C

Temperature Range

3 °C to 99 °C

Control Accuracy

+/- 0.1 °C

Software

User specific quick start of the last five programs, program preview prior to start, toggle between
spreadsheet and graphical programming mode, Linear Gradient Tool1, generate service info files (SINF),extended self-test, adjustable ramp rates, view gradient temperature graph1, PC control via Ethernet, comprehensive user administration tool with individual rights settings, Protocol Wizard

Display

7‘‘ Color Touchscreen

Auto restart after power failure

Yes

High Performance Smart Lid (HPSL) Technology

Yes

Lid Temperature Range

30 °C to 110 °C

Power consumption

850 Watt

Power Supply

100, 115, 230 Volt, 50-60 Hz

Noise emission

Very low, max. 45 dB

Interfaces2

USB A, Ethernet

Working conditions

15 °C to 35 °C, 70 % air humidity, max. 2000 m NN

Dimensions (W x D x H)

277 mm x 457 mm x 264 mm

Dimensions (W x D x H) with lid opened

277 mm x 457 mm x 414 mm

Weight

15 kg

* measured inside the block

1 Only for model type “G” featuring gradient function

2 The network cable must be at least performance class Cat 5e and the cable configuration has to be STP

Instrument

Biometra TAdvanced 60

Biometra TAdvanced 384

Capacity

60 tubes
0.5 ml

384 well microplates

Block

Aluminum

Aluminum

Block coating

Special Alloy

Special Alloy

Block Exchange

Quick-X-Change

Quick-X-Change

Block Exchange time

less than 10s

less than 10s

Max. heating rate*

6.0 °C/sec

4.0 °C/sec

Max. cooling rate*

4.0 °C/sec

2.0 °C/sec

Avg. Heating Rate*

5.5 °C/sec

3.8 °C/sec

Avg. Cooling Rate*

3.0 °C/sec

1.7 °C/sec

Max./min. Gradient span1

30 °C

24°C

Temperature Uniformity

95 °C  ± 0.60 °C after 15s

70 °C  ± 0.30 °C after 15s

55 °C  ± 0.20 °C after 15s

95 °C  ± 0.50 °C after 15s

70 °C  ±0.25 °C after 15s

55 °C  ± 0.15 °C after 15s

Gradient Temperature Range1

20 °C to 99 °C

20 °C to 99 °C

Temperature Range

3 °C to 99 °C

Control Accuracy

+/- 0.1 °C

Software

User specific quick start of the last five programs, program preview prior to start, toggle between
spreadsheet and graphical programming mode, Linear Gradient Tool1, generate service info files (SINF),extended self-test, adjustable ramp rates, view gradient temperature graph1, PC control via Ethernet, comprehensive user administration tool with individual rights settings, Protocol Wizard

Display

7‘‘ Color Touchscreen

Auto restart after power failure

Yes

High Performance Smart Lid (HPSL) Technology

Yes

Lid Temperature Range

30 °C to 110 °C

Power consumption

850 Watt

Power Supply

100, 115, 230 Volt, 50-60 Hz

Noise emission

Very low, max. 45 dB

Interfaces2

USB A, Ethernet

Working conditions

15 °C to 35 °C, 70 % air humidity, max. 2000 m NN

Dimensions (W x D x H)

277 mm x 457 mm x 264 mm

Dimensions (W x D x H) with lid opened

277 mm x 457 mm x 414 mm

Weight

15 kg

* measured inside the block

1 Only for model type “G” featuring gradient function

2 The network cable must be at least performance class Cat 5e and the cable configuration has to be STP

Instrument

Biometra
TAdvanced
Twin 48/48G

Biometra
TAdvanced
Twin 30

Biometra
TAdvanced
Twin combi

Capacity

2 x 48 x 0.2 ml tubes/
2 x 48- well microtiter
plate /2 x 6 x 8-well
strips, 0.2 ml

2 x 30 x 0.5 ml tubes 2       

2 x 48 x 0.2 ml tubes/
2 x 6 x 8-well strips,
0.2 ml/2 x 48-well
microtiter plate/
2 x 18 x 0.5 ml tube            

Block

Aluminum, special
alloy

Aluminum, special
alloy

Aluminum, special
alloy

Max. heating rate1

5.2 °C/s

4.2 °C/s

3.1 °C/s

Max./min. gradient2

20 °C/0.1 °C

-

-

Gradient temperature
range2

20 °C to 99 °C

Temperature uniformity
at 55 °C after 15 s

± 0.20 °C

± 0.20 °C

± 0.20 °C

Temperature range

3 °C to 99 °C

3 °C to 99 °C

3 °C to 99 °C

Control accuracy

± 0.1 °C

± 0.1 °C

± 0.1 °C

Lid temperature
range

30 °C to 110 °C

30 °C to 110 °C

30 °C to 110 °C

Program memory

350 programs in up to
30 user directories

350 programs in up to
30 user directories

350 programs in up to
30 user directories

Dimensions
(W x D x H, mm)

277 x 457 x 264

277 x 457 x 264

277 x 457 x 264

G = with gradient function
1 measured within sample block
2 applies only to cycler models with gradient function
For more technical details please refer to the corresponding Technical Data sheets.

Order Info

Instruments

Order number

Description

Capacity

846-x-070-211

Biometra TAdvanced 96

96 well
0.2 ml tubes, plates,
strips

846-x-070-201

Biometra TAdvanced 96 G

96 well
0.2 ml tubes, plates,
strips

846-x-070-241

Biometra TAdvanced 96 SG

96 well
0.2 ml tubes, plates,
strips

846-x-070-251

Biometra TAdvanced 96 S

96 well
0.2 ml tubes, plates,
strips

846-x-070-210

Biometra TAdvanced 60

60 well   
0.5 ml tubes

846-x-070-200

Biometra TAdvanced 60 G   

60 well   
0.5 ml tubes

846-x-070-224

Biometra TAdvanced 384

384 well
384 well plates

846-x-070-214

Biometra TAdvanced 384 G

384 well
384 well plates

846-x-070-212

Biometra TAdvanced Twin 48

2 x 48-well block (0.2 ml)

846-x-070-202

Biometra TAdvanced Twin 48 G

2 x 48-well block (0.2 ml)
and gradient function

846-x-070-213

Biometra TAdvanced Twin 30

2 x 30-well block (0.5 ml)

846-x-070-215

Biometra TAdvanced Twin combi

2 x 48-well (0.2 ml) and
2 x 18-well (0.5 ml) block

G = Gradient
x = 2 for 230 V, 4 for 115 V, 5 for 100 V

Block modules and base unit

Order number

Description

Capacity

846-070-231

Biometra TAdvanced Block Module 96

96 well
0.2 ml tubes, plates, strips

846-070-221

Biometra TAdvanced Block Module 96 G

96 well
0.2 ml tubes, plates, strips

846-070-271

Biometra TAdvanced Block Module 96 S

96 well
0.2 ml tubes, plates, strips

846-070-261

Biometra TAdvanced Blockmodul 96 SG

96 well
0.2 ml tubes, plates, strips

846-070-230

Biometra TAdvanced Block Module 60

60 well
0.5 ml tubes

846-070-220

Biometra TAdvanced Block Module 60 G

60 well
0.5 ml tubes

846-070-234

Biometra TAdvanced Block Module 384

384 well plates

846-070-224

Biometra TAdvanced Block Module 384 G

384 well plates

846-070-232

Biometra TAdvanced Twin Block Module 48

2 x 48-well block (0.2 ml)

846-070-222

Biometra TAdvanced Twin Block Module 48 G

2 x 48-well block (0.2 ml)
and gradient function

846-070-233

Biometra TAdvanced Twin Block Module 30

2 x 30-well block (0.5 ml)

846-070-235

Biometra TAdvanced Twin Block Module combi

2 x 48-well (0.2 ml) and
2 x 18-well (0.5 ml) block

846-x-070-280

Biometra TAdvanced Base Unit

-

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