CyBio® Well vario

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Overview

96, 384 and 1536 Channel Simultaneous Pipettor

The CyBio® Well vario includes an automated base which accepts different interchangeable simultaneous pipetting heads. The heads can be changed quickly and easily either at the front or the back of the instrument. After head exchanges the calibration maintains.

A working volume range of four orders of magnitude allows liquid transfers from 25 nl up to 250 µl on one platform, either with 96 or 384 disposable tips. The CyBio® Well vario adapts into any screening environment and it is compatible with all other accessories of the CyBio® Well family.

The innovative CyBio® Composer Software. supports the flexibility of the system and immediately detects the new head. 

  • Extremely flexible through enormous volume spectrum
  • Highest precision in the whole volume range
  • Unique pipetting technology prevents cross contamination
  • Easy application set-up using CyBio® Composer software
  • Saves reagent costs with accurate low volume pipetting

Brochure CyBioCyBio® Well vario

Brochure Capillary Head

Flyer 384 - 25 μl Head

Flyer 1536 Pipetting Head

Brochure uHTS MALDI Sample Preparation — Beyond Spotting

Pipetting Heads

Head 96/25 µl

Parallel pipetting of 96 samples in 96, 384 and 1536 well microplates Volume freely selectable in 0,01 µl steps with a working volume up to 25 µl.

Head 96/60 µl

Parallel pipetting of 96 samples in 96, 384 and 1536 well microplates Volume freely selectable in 0,01 µl steps with a working volume up to 60 µl.

Head 96/250 µl

Parallel pipetting of 96 samples in 96, 384 shallow or deep well microplates Volume freely selectable in 0.01 µl steps with a working volume up to 250 µl.

Head 384/25 µl

Parallel pipetting of 384 samples in 384 and 1536 well microplates Volume freely selectable in 0.01 µl steps with a working volume up to 25 µl.

Head 384/60 µl

Parallel pipetting of 384 samples in 384 and 1536 well microplates Volume freely selectable in 0.01 µl steps with a working volume up to 60 µl.

Head 1536/8 µl

Parallel pipetting of 1536 samples in 1536 well microplates Volume freely selectable in 0.01 µl steps with a working volume up to 8 µl.

Capillary Head

Optimized for pipetting of DMSO solutions into dry microplates Available with fix working volumes of 50, 100, 250, 500 nl with ceramic capillaries parallel pipetting of 96 or 384 samples in 96, 384 an 1536 well microplates due to exchangeable magazines.

Specifications

Head 96/25 µl

Volume range: 
0.2-25 µl
Precision [CV in %]* of specified volume range:
0.2 ≤ 10%
2-5 µl ≤ 2%
>5-2 5µl ≤ 1%

Head 96/60 µl

Volume range:
1–60 µl
Precision [CV in %]* of specified volume range:
3-5 µl ≤ 2%
>5-60 µl ≤ 1%

Head 96/250 µl

Volume range: :
1-250 µl
Precision [CV in %]* of specified volume range:
25-100 µl ≤ 2%
25-250 µl ≤ 1%

Head 384/25 µl

Volume range:
0.2-25 µl
Precision [CV in %]* of specified volume range:
2-5 µl ≤ 2%
>5-25 µl ≤ 1%

Head 384/60 µl

Volume range:
1–60 µl
Precision [CV in %]* of specified volume range:
3-5 µl ≤ 2%
>5-60 µl ≤ 1%

Head 1536/8 µl

Volume range:
1–8 µl
Precision [CV in %]* of specified volume range:
2-5 µl ≤ 2%
>5 µl ≤ 1%

Capillary Head

Volume range:
0.050-1 µl
Precision [CV in %]* of specified volume range:
0.025-1,0 µl ≤ 10%


*The specification of precision and trueness is based on the Analytik Jena internal gravimetric and photometric standard measurement procedure, which is published as Annex B7 in the ISO IWA 15 document ” Specification and method for the determination of volumetric performance of automated liquid handling systems“ (www.IWA15.org). The Application Note „Photometric and Gravimetric Liquid Handling Check Procedure to determine the Random Error (Precision) and the Systematic Error (Accuracy) of Automated Liquid Handling Systems (ALHS)“ describes this measuremet procedure in detail.
Every modification of this method may influence the results.

Technical Data

CyBio® Well vario
Weight39,5 kg with 3,4 and 5 place linear transporting unit

49 kg with 10-place circular transporting unit
Pipetting Channels96, 384, 1536
Pipetting TipsDisposable tips/capillaries
Plate Formats96, 384, 1536
Plate Capacity3 with 3-place linear transporting unit

4 with 4-place linear transporting unit

5 with 5-place linear transporting unit

10 with 10-place circular transporting unit
Footprint (W x D in mm)960 x 370 mm with 3-place linear transporting unit

1300 x 370 mm with 4-place linear transporting unit

1650 x 370 mm with 5-place linear transporting unit

700 x 895 mm with 10-place circular transporting unit
Height (mm)772.5 mm
Volume RangeWet pipetting: 50 nl bis 250 μl

Dry pipetting: 200 nl bis 250 μl

Software

The CyBio® Well vario is controlled by the CyBio® Composer Software.

Applications

A three, four, five or ten - position carriage handles high-precision pipetting needs with high flexibility and ample deck space to run the application successfully. The high flexibility of the CyBio® Composer Software supports any application.

  • Reformatting
  • Replication
  • Plate coating
  • Biochemical assays
  • ADME and cytotoxicity assays
  • Compound management Molecular Biology assays (RNA silencing)
  • Cell handling
  • uHTS MALDI Sample Preparation — Beyond Spotting

Application   

Application Reports

Technical Reports

Precision and Accuracy of the CyBio® Well vario as determined by using Artel’s Dual Dye Ratiometric Calibration Technology

"How to Use" Guide for the Capillary Head of the CyBio® Well vario

Start-up Routine and Tip Washing Efficiency Data of the Active Deep Well Tip Wash Station 384

Presicion of Different 96-Capillary Type Magazines of the CyBio® Well vario Capillary Head — Example Data

Photometric and Gravimetric Liquid Handling Check Procedure to determine the Random Error (Precision) and the Systematic Error (Accuracy) of Automated Liquid Handling Systems (ALHS)

Precision of the new Ceramic Type Capillary Magazines 384 of the CyBio® Well vario Capillary Head — Example Data

 

Automated TRANSIL® HSA Binding Kit on CyBio® Well vario

Precision of Different 384-Capillary Type Magazines of the CyBio® Well vario Capillary Head — Example Data

Optimized Washing of Disposable Tips after Transfer of DNA Samples

Precision of The CyBio® Well vario 96/25 µL Head, Example Data of Different Liquids, Pipetting Modes and Disposable Tips with Fluorescence Readout

Results of Pipetting of Small Volumes using a 384 CyBio® Well

Precision of the CyBio® Well vario 96/60 µl Head, Example Data of Different Liquids, Pipetting Modes and Disposable Tips with Fluorescence Readout

Performance and reliability testing of a new capillary based non-contact liquid handling system under real HTS conditions

Precision of The CyBio® Well vario 96/250 µL Head, Example Data of Different Liquids, Pipetting Modes and Disposable Tips with Fluorescence Readout

Performance and reliability testing of a new capillary based non-contact liquid handling system

Precision of The CyBio® Well vario 384/2.5 µL Head, Example Data of Different Liquids, Pipetting Modes and Disposable Tips with Fluorescence Readout

Implementation of a CyBio® Integrated System to Aliquot Amplified DNA and Dispense DNA Sequencing Chemistry

Precision of the CyBio® Well vario 384/25 µl Head

Precise low volume compound handling with the new Nanoliter Head of CyBio® Well vario

Precision of the CyBio® Well vario 384/40 µL Head, Example Data of Different Liquids, Pipetting Modes and Disposable Tips with Fluorescence Readout

 

Precision of the CyBio® Well vario 384/60 µL Head, Example Data of Different Liquids, Pipetting Modes and Disposable Tips with Fluorescence Readout

 

Stability of the Precision of Different CyBi®-Well vario Heads after Multiple Tip Washing Routines

 

Measuring the Precision and Accuracy of the CyBio® Well vario 384/25 μl Head using the ARTEL Multichannel Verification System (MVS®)

 

Performance Data demonstrating the Efficiency of the Tip Wash Station of the CyBio® Well Family

Accessories

Plate Transfer Unit

This additional module can be mounted to the CyBio® Well or CyBio® Well vario and allows the automatic relocation of a microplate to any carriage position.

Microplate adapter

Micro plate adapter allow you to use any type of micro plates of various manufacturers on our devices incl. adapter for specific application requirements.
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Automated Reservoir Filling

The reagent reservoirs are designed for the storage and automatically refilling of liquids, such as buffers, DMSO…
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Barcode Handling

For creation of barcodes, labeling of microplates as well as reading of barcodes within the process we offer tailor-made solutions.
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Tip Wash Station

With the aid of these wash modules, tips in the 96 and 384 format can be washed automatically with pump-supported (active) inflow and drain, which helps you to reduce disposable costs.
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Plate Handling and Storage

Efficient microplate storage with stackers enables fully automated processing of large batches of plates and increases your walk-away time.
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Tip Changer

For high throughput applications, where tip changing is necessary, the TipChanger can store up to 100 tip racks.

Videos

Full Automation CyBio® Well vario

Variable multichannel pipettor.

CyBio® Well vario 1536 Head CyBio® Well vario 1536 Head

The pipetting head uses CyBio®

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